Rabies vaccines can be administered via different routes, but the most common route is intramuscular injection. In pre-exposure prophylaxis, a series of three doses of the vaccine is typically administered on days 0, 7, and 21 or 28. This primary vaccination series provides long-lasting protection against rabies. Booster doses may be recommended for individuals at high risk of exposure, such as veterinarians, animal handlers, and travelers to rabies-endemic areas.

In post-exposure prophylaxis, the vaccine is administered immediately after exposure to the rabies virus, usually along with rabies immunoglobulin. The post-exposure vaccination schedule may vary depending on the severity of the exposure and the type of vaccine used. In general, a series of four or five doses of the vaccine is administered over a period of 14 to 28 days.