Eccogene, Inc., a clinical stage biopharmaceutical company focused on discovery and development of metabolic and immunologic therapeutics, announced the initiation of a Phase 1a clinical trial evaluating ECC0509, an oral inhibitor of semicarbazide-sensitive amine oxidase (SSAO)/vascular adhesion protein-1 (VAP-1), as a potentially novel therapy for patients with non-alcoholic steatohepatitis (NASH) and osteoarthritis (OA) associated pain.

The trial is a Phase 1, randomized, double-blind, placebo-controlled, sequential single- and multiple ascending dose clinical trial to evaluate the safety, pharmacokinetics, pharmacodynamics of ECC0509 in healthy volunteers. All participants will receive either placebo, or a single dose or multiple doses of ECC0509. Preliminary topline data from the clinical trial is expected in Q1 2022.

About Eccogene

Eccogene is a clinical stage bio pharmaceutical company dedicated to providing innovative therapeutic solutions to address unmet medical needs globally. The company focuses on discovery and development of translational medicine in metabolic and immune-related diseases.

About ECC0509

ECC0509 is a highly selective and peripherally distributed small molecule inhibitor of SSAO/VAP-1, elevated activity of which is associated with pathophysiology of human disorders including NASH and OA. In Eccogene non-clinical studies, ECC0509 was shown to be well-absorbed, safe at the anticipated human dose range, and efficacious in animal models of NASH and OA pain following oral administration.