What is Coenzyme Q10?

Coenzyme Q10 is a natural, lipid-soluble compound found in the body. It is used for many functions such as the production of energy, especially in cells that demand high rates of metabolic energy.  In addition, it is considered a powerful antioxidant, protecting the body’s cells from oxidative stress. Common brand names are CoQ10, Ubiquinone, and Qunol?.

Coenzyme Q10 Forms and Specifications

Coenzyme Q10 is available in several different forms and specifications including coenzyme Q10 API powder, coenzyme Q10 liquid, and coenzyme Q10 capsules and gummies.

Coenzyme Q10 API Powder 99%

Raw material of coenzyme Q10 API powder (CAS 303-98-0) is in the form of a yellow to orange crystalline powder. The specification from Chinese manufacturers Fujian Fukang Pharmaceutical Co., Ltd., Zhejiang NHU Company, Ltd., Xiamen Kingdomway Vitamin LTD., Hangzhou Kexing Biochem Co., Ltd., Anhui Biochem United Pharmaceutical Co., Ltd, and Shenzhou Biology &Technology Co., Ltd. is 99% min.

Coenzyme Q10 Liquid

Coenzyme Q10 can be found over the counter in a liquid formulation containing 100 mg of coenzyme Q10 per 10 mL.  

Coenzyme Q10 Capsules and Gummies

Coenzyme Q10 capsules and gummies can also be found over the counter.

Mechanism of Action of Coenzyme Q10

Coenzyme Q10 is a cofactor that is needed in the mitochondrial electron transport chain, shuttling electrons and protons (“PubChem Compound Summary for CID 5281915, Coenzyme Q10”). It receives electrons from the complex I and II, which is important for ATP production (“PubChem Compound Summary for CID 5281915, Coenzyme Q10”). Coenzyme Q10 also expresses antioxidant functions, protecting the body’s cells against oxidative stress. 

Coenzyme Q10 API Manufacturing Process

The manufacturing process of coenzyme Q10 API is performed under proper quality control systems that comply with the regulations of international Good Manufacturing Practice (GMP) to produce safe and high-quality active pharmaceutical ingredients.  

The manufacturing process of coenzyme Q10 includes “solanesol as a starting substrate and the source of the isoprenoid tail” which is then “combined with the quinone head” (Lee). Coenzyme Q10 can also be produced through microbial biosynthesis (Lee).

Impurities are then extracted from the active ingredient. Coenzyme Q10 is tested and purified according to GMP and quality standards until it achieves 99% min purity specification.

Benefits of Coenzyme Q10

Coenzyme Q10 has been shown to be beneficial for cardiac health and for the prevention of an array of other health conditions. It has also been shown to decrease muscle pain in patients who take statin drugs for cholesterol. In addition, it is an antioxidant that helps protect the body’s cells from oxidative stress. 

Coenzyme Q10 Dosage

The usual dose of coenzyme Q10 is 50 mg – 200 mg daily.

Side Effects of Coenzyme Q10

Side effects of coenzyme Q10 may include nausea, headache, diarrhea, and skin rashes.

Where can you find the bulk price of Coenzyme Q10 API Powder? 

Below are some manufacturers in China who make API ingredients.

Coenzyme Q10 API Manufacturers in China:

Chinese manufacturers, Fujian Fukang Pharmaceutical Co., Ltd., Zhejiang NHU Company, Ltd., Xiamen Kingdomway Vitamin LTD., Hangzhou Kexing Biochem Co., Ltd., Anhui Biochem United Pharmaceutical Co., Ltd., and Shenzhou Biology & Technology Co., Ltd. manufacture raw material of coenzyme Q10 API powder 99% in bulk. If you need a price quote, certificate of analysis (COA), or a detailed specification sheet, please visit these professional manufacturers on www.25793.cn.  

Fujian Fukang Pharmaceutical Co., Ltd.

Fujian Fukang Pharmaceutical Co., Ltd. follows innovation of API research and development. They specialize in biological fermentation products, chemically synthesized antiviral APIs and dosage forms, and vet products. They hold CEP certificates from EDQM and EU GMP certification while successfully passing US FDA inspections and GMP inspections by Japan PMDA. They are dedicated to producing the highest-quality products to serve the health and well-being of the public. 

For more information about Fujian Fukang Pharmaceutical Co., Ltd., visit www.25793.cn. 

Zhejiang NHU Company, Ltd.

Zhejiang NHU Company, Ltd. manufactures pharmaceutical products and human and animal nutritional products. They specialize in fat-soluble vitamins and carotenoids, raw materials of synthetic and biological fermentation, and pharmaceutical products with dosage forms. They follow safety, environmental protection, and occupational health management systems in accordance with ISO 14001 and OHSAS18001. They have passed API GMP inspections by the EU, Australia TGA, WHO, and the US FDA. 

For more information about Zhejiang NHU Company, Ltd., visit www.25793.cn. 

Xiamen Kingdomway Vitamin LTD.

Established in 1997, Xiamen Kingdomway Vitamin LTD. has been recognized as one of Xiamen’s first high-tech companies. They were listed in Shenzhen Stock Exchange in 2011. They are dedicated to providing quality and safe nutrition fortifiers and bio-medical field. With experience in research and technological advancements, Xiamen Kingdomway Vitamin LTD. has participated in regional and national scientific and technological projects, including National Torch Projects. They hold ISO9001, ISO 14001, ISO22000, HAACP, FAMI-QS, Kosher and Halal certifications. They specialize in the manufacturing of Coenzyme Q10, Vitamin A, Vitamin D3, ARA, and Microalgea DHA. 

For more information about Xiamen Kingdomway Vitamin LTD., visit www.25793.cn. 

Hangzhou Kexing Biochem Co., Ltd.

Established in 1995, Hangzhou Kexing Biochem Co., Ltd. specializes in the research, manufacturing, and sales of feed additives and health products. In 1998, they were recognized as a “hi-and new-tech enterprise” in Zheijang province. They are known in the US, Europe, and Latin America for their biotin and CoQ10 manufacturing and sales.

For more information about Hangzhou Kexing Biochem Co., Ltd., visit www.25793.cn. 

Anhui Biochem United Pharmaceutical Co., Ltd.

Located in Fuyang City, Auhui Province, Anhui Biochem United Pharmaceutical Co., Ltd. specializes in research, manufacturing, and sales of anti-HIV and anti-HBC chiral drugs. They have one of the largest and most complete diversity of anti-HBV and anti-HIV/AIDS API manufacturing bases in China. 

For more information about Anhui Biochem United Pharmaceutical Co., Ltd., visit www.25793.cn. 

Shenzhou Biology & Technology Co., Ltd.

Shenzhou Biology & Technology Co., Ltd. was established in 2006 and is located in Tuoketuo Industrial Park, Huhehot City, Inner Mongolia Autonomous Region, P.R. China. They also have an office in Beijing city, P.R. China. They specialize in the manufacturing of CoQ10 and VB2 with ISO9001, FAMI-QS, FSMS, HALAL, KOSHER, USP, FDA, and QMS certifications. 

For more information about Shenzhou Biology & Technology Co., Ltd., visit www.25793.cn. 

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FAQ

What is the market size for coenzyme Q10?

• In 2018, the global coenzyme Q10 market size surpassed USD 470 million and is expected to grow more than 10% compound annual growth rate through 2026, according to Global Market Insights.

References:

1. Ahuja K, Mamtani K. Coenzyme Q10 Market Size by Application (Pharmaceuticals, Dietary Supplements, Cosmetics), Industry Analysis Report, Regional Outlook, Growth Potential, Competitive Market Share & Forecast, 2019-2026. Global Market Insights. https://www.gminsights.com/industry-analysis/coenzyme-q10-coq10-market. Published November 2019. Accessed June 8, 2021.

2. Company Profile of Anhui Biochem United Pharmaceutical Co., Ltd. PharmaSources. http://www.25793.cn/company-profile/anhui-biochem-united-pharmaceutical-co-l-userId-156.html. Accessed June 8, 2021.

3. Company Profile of Fujian Fukang Pharmaceutical Co., Ltd. PharmaSources. http://www.25793.cn/company-profile/fujian-fukang-pharmaceutical-co-ltd-userId-155.html. Accessed June 8, 2021.

4. Company Profile of Hangzhou Kexing Biochem Co., Ltd. PharmaSources. http://www.25793.cn/company-profile/hangzhou-kexing-biochem-co-ltd-userId-9976.html. Accessed June 8, 2021.

5. Company Profile of Shenzhou Biology & Technology Co., Ltd. PharmaSources. http://www.25793.cn/company-profile/shenzhou-biology-technology-co-ltd-userId-21091.html. Accessed June 8, 2021.

6. Company Profile of Xiamen Kingdomway Vitamin LTD. PharmaSources.  http://www.25793.cn/company-profile/xiamen-kingdomway-vitamin-ltd-userId-16669.html. Accessed June 8, 2021.

7. Company Profile of Zhejiang NHU Company Ltd. PharmaSources.  http://www.25793.cn/company-profile/zhejiang-nhu-company-ltd-userId-143.html. Accessed June 8, 2021.

8. Kubala, Jillian, MS, RD. CoQ10 Dosage: How Much Should You Take per Day? healthline. 

https://www.healthline.com/nutrition/coq10-dosage. Written on September 4, 2018. Accessed June 8, 2021.

9. Kubala, Jillian, MS, RD. CoQ10 Dosage: How Much Should You Take Per Day? healthline. https://www.healthline.com/nutrition/coq10-dosage#dosages. Written September 4, 2018. Accessed June 8, 2021.

10. Kubala, Jillian, MS, RD. CoQ10 Dosage: How Much Should You Take Per Day? healthline. https://www.healthline.com/nutrition/coq10-dosage#side-effects. Written September 4, 2018. Accessed June 8, 2021.

11. Kubala, Jillian, MS, RD. CoQ10 Dosage: How Much Should You Take Per Day? healthline. https://www.healthline.com/nutrition/coq10-dosage#what-it-is. Written September 4, 2018. Accessed June 8, 2021.

12. Lee, S.Q.E., Tan, T.S., Kawamukai, M. et al. Cellular factories for coenzyme Q10 production. Microb Cell Fact. 16, 39 (2017). https://doi.org/10.1186/s12934-017-0646-4. Accessed June 8, 2021.

13. National Center for Biotechnology Information. PubChem Compound Summary for CID 5281915, Coenzyme Q10. https://pubchem.ncbi.nlm.nih.gov/compound/Coenzyme-Q10. Accessed June 8, 2021.

14. Qunol? Liquid CoQ10, 100 mg. Qunol?. https://www.qunol.com/collections/shop/products/qunol-liquid-coq10. Accessed June 8, 2021.

15. Ubidecarenone. DrugBank. https://go.drugbank.com/drugs/DB09270. Accessed June 8, 2021.