August 4,2020

Led by content leads, Alok Srivastava, MD, and Glenn Pierce, MD, PhD, WFH Vice-President, Medical, this 3rd edition of the World Federation of Hemophilia (WFH) Guidelines for the Management of Hemophilia offers up-to-date guidance and practical recommendations on the diagnosis and management of hemophilia, including the management of musculoskeletal complications and inhibitors, updates to laboratory diagnosis and genetic assessments, as well as new recommendations on outcome assessments.

Informed by the best available evidence and supplemented with expert opinion and patient preference, the more than 300 practical recommendations in these guidelines were developed by consensus using the "Trustworthy Consensus-Based Statement" process to ensure reliable guidance. The guideline panel was composed of clinically and geographically diverse experts in hemophilia care, as well as 25% membership of people with hemophilia and caregivers.

These high-quality, evidence- and expert-informed treatment guidelines offer a means to bridge the gap between treatment practices and care around the world. They offer a set of practical recommendations intended to improve the quality of care globally, promote effective clinical interventions and decrease variations in clinical practice. Where recommendations lack adequate evidence, these guidelines can stimulate appropriate studies.

The World Federation of Hemophilia sincerely thanks the > 100 contributors who made the development of these guidelines possible--all under very tight timelines. A special thank you to the hemophilia care experts, people with hemophilia and reviewers who generously gave their time and expertise in order to ensure that each chapter attained the highest quality standards possible. As a result of their generosity, we are able to provide health care providers and people with hemophilia around the world with a set of invaluable recommendations on which to base their care. Thank you also to the external reviewers and Haemophilia journal peer reviewers who provided feedback under the very special current circumstances of the COVID-19 crisis.