July 16,2020

Harbour BioMed (HBM), a global clinical stage biopharmaceutical company, today announced that the Company presented preclinical data from a fully human CD73 antibody (HBM1007) in an e-poster at the American Association for Cancer Research (AACR) Virtual Annual Meeting II held from June 22-24, 2020.

HBM1007 is a fully human mAb against CD73 which is an ecto-enzyme expressed on stromal cells and tumors that converts extracellular adenosine monophosphate (AMP) to adenosine. High concentration of adenosine, predominantly signaling through the A2A receptor, suppresses innate and adaptive immune cell responses leading to tumor escape from immune surveillance. With unique epitopes to recognize CD73, HBM1007 works through dual modes of action: first, it can block the enzymatic activity of both membrane and soluble CD73 independent of AMP concentration, suggesting its sustainable activity in TME, and second, it reduces the surface expression of CD73. As a result, both enzymatic and non-enzymatic dependent functions of CD73 were significantly reduced.

"HBM1007 is a fully human anti-CD73 antibody generated from H2L2 Harbour Mice? platform with excellent anti-tumor potency and impressive developability. HBM1007 shows great potential as a promising anti-tumor monotherapy for patients with high CD73 expression. We also expect HBM1007 will benefit broader patient populations with its unique dual mechanism of actions as combination therapies." said Dr. Jingsong Wang, Founder, Chairman and CEO of Harbour BioMed.