Boston Biomedical has initiated clinical trial activities for DSP-0509, an investigational Toll-like receptor (TLR) 7 agonist. DSP-0509 is hypothesized to induce cytokine production, activate cytotoxic T lymphocytes, and sustain the immune-mediated antitumor activity by induction of immune system memory cells. The phase 1, open-label, multicenter trial will evaluate the safety and pharmacokinetic profile of intravenously administered DSP-0509 in adult patients with advanced solid tumors that are refractory to standard treatment.

"The initiation of this trial represents an important milestone for Boston Biomedical and reinforces the depth of our oncology pipeline," said Patricia S. Andrews, Chief Executive Officer, Boston Biomedical, Inc. "We are looking forward to exploring the safety and activity of DSP-0509 and understanding more about its potential in treating cancer."

DSP-0509 is an investigational synthetic Toll-like receptor (TLR) 7 agonist. In preclinical models, DSP-0509 was shown to promote the cytokine induction and cytotoxic T lymphocyte (CTL) activation mediated by agonistic effect of TLR 7 expressed in plasmacytoid dendritic cells. DSP-0509 is hypothesized to sustain the immune-mediated anticancer activity by induction of immune system memory cells and is currently being evaluated in a phase 1 clinical trial.

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