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Basic Info

  • Grade: pharmaceutical grade

    Factory Location: china

    Main Sales Markets: North America,Central/South America,Western Europe,Eastern Europe,Australasia,Eastern Europe,Australasia,Asia,Middle East,Africa

  • Packaging Information: 1kg/bag

  • Sample Provided: no

    Payment Terms: Bank transfer

    The organophosphorus compound triethyl phosphorylacetate is an important class of chemicals that exhibit many excellent properties. The formation of phosphorus-carbon bonds by Arbuzov reaction is an effective way to prepare compounds such as hydrocarbon phosphonates, phosphinates and phosphine oxides. Arbuzov reaction was first discovered by Michaelis in 1898, and later developed by Arbuzov, mainly to prepare hydrocarbon phosphates from halogenated hydrocarbons and phosphate esters as substrate reactions, halogenChemicalbook hydrocarbons in the Arbuzov reaction difficulty depends on two points: one is the polarization of carbon halide bonds, the stronger the polarity, the easier it is to carry out, so RI>RBr > RCl； The second is the spatial barrier of the hydrocarbon group, the larger the barrier, the more difficult it is to carry out. Generally, Arbuzov reaction is difficult for aryl halides, and some chlorinated hydrocarbons have a limited reaction temperature due to low activity, and the reaction time is too long, which greatly limits the application of the reaction in organic synthesis.
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