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Aminoglycoside antibiotic G418 108321-42-2 litol 72432-03-2

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Specification:

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G418 (Geneticin) is an aminoglycoside antibiotic similar in structure to gentamicin B1. It is produced by Micromonospora rhodorangea. G418 is produced by fermentation and isolation processes and the G418 producing strainMicromonospora rhodorangea produces many other gentamycins while producing G418. The common impurities of G418 include gentamycin X2, gentamicin A, gentamycin C1, C2, C1a and C2a. The quality of G418 is not based on just the potency, but more on the selectivity defined by the killing curve of the sensitive cells vs the resistant cells. A good G418 product has the lowest LD₅₀ for sensitive cells (such as NIH 3T3) and the highest LD₅₀ (can be up to 5,000 μg/ml) for resistant cells (NIH 3T3 transfected with resistant genes). Gentamycins have almost no selectivity, except gentamycin X2.

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